Schonbrunn A, Gu Y Z, Dournard P, Beaudet A, Tannenbaum G S, Brown P J
Department of Pharmacology, University of Texas Medical School, Houston 77225, USA.
Metabolism. 1996 Aug;45(8 Suppl 1):8-11. doi: 10.1016/s0026-0495(96)90069-4.
The five cloned somatostatin (SRIF) receptors (ssts) are presumed to subserve unique biological roles by virtue of their tissue-specific expression and particular signal transduction mechanisms. However, the function of any individual sst subtype in its normal physiological milieu is not understood, because tissues and cells often express multiple ssts and, in the absence of receptor-specific SRIF analogs, the actions of individual receptors cannot be identified. To unravel the physiological role and signaling mechanism of the ssts, we have generated receptor subtype-specific antibodies and used these antibodies to determine the distribution of the receptor proteins and to identify the signal-transducing molecules with which particular sst subtypes interact.
五种克隆的生长抑素（SRIF）受体（ssts）因其组织特异性表达和特定的信号转导机制，被认为具有独特的生物学作用。然而，任何一种sst亚型在其正常生理环境中的功能尚不清楚，因为组织和细胞通常表达多种ssts，并且在缺乏受体特异性SRIF类似物的情况下，无法确定单个受体的作用。为了阐明ssts的生理作用和信号传导机制，我们制备了受体亚型特异性抗体，并使用这些抗体来确定受体蛋白的分布，以及识别特定sst亚型与之相互作用的信号转导分子。
