Vasina I G, Frolov E P, Serebriakov N G
Zh Mikrobiol Epidemiol Immunobiol. 1975 Sep;0(9):88-92.
Experiments were carried out on linear mice immunized with sheep erythrocytes; it was found that the primary immune respose developed against the background of significant changes in the state of the sympathico-adrenal system, whose activity was determined by the dynamics of catecholamines in the blood and in the tissues of a number of organs, including the thymus, the spleen and the lymph nodes. By comparing the value of specific and neurohumoral indices it was revealed that the neurohumoral shifts preceded the maximal development of the immune response. On the example of studying the catecholamine dynamics the opinion on a close association between the state of the regulatory mechanisms and the effector formations responsible for the formation of specific immunological reactions was confirmed. It is suggested that a full-value immunological response developed on condition of activation of the sympathico-adrenal system.
对用绵羊红细胞免疫的线性小鼠进行了实验；发现初次免疫反应是在交感 - 肾上腺系统状态发生显著变化的背景下发展起来的，其活性由血液以及包括胸腺、脾脏和淋巴结在内的许多器官组织中的儿茶酚胺动态决定。通过比较特异性和神经体液指标的值，发现神经体液变化先于免疫反应的最大发展。以研究儿茶酚胺动态为例，证实了关于调节机制状态与负责特异性免疫反应形成的效应器结构之间密切关联的观点。有人提出，在交感 - 肾上腺系统激活的条件下会产生充分的免疫反应。
