Liu K L, Sassard J, Benzoni D
Departement de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique, Faculté de Pharmacie, Lyon, France.
Am J Physiol. 1996 Aug;271(2 Pt 2):R346-51. doi: 10.1152/ajpregu.1996.271.2.R346.
To assess the role of the renin-angiotensin system (RAS) in the renal alterations of the lyon hypertensive (LH) rat, the renal function of LH rats and of their normotensive (LN) controls was studied at different pressure levels after an early and chronic blockade of the RAS by perindopril (3 mg.kg-1.day-1 orally from 3 to 15 wk of age) and after an acute infusion of angiotensin II (ANG II, 10 or 50 ng.kg-1.min-1). Over the range of renal perfusion pressures studied (115-165 mmHg), control LH differed from LN rats by an increased preglomerular vasoconstriction and a blunted pressure-natriuresis curve. Perindopril fully prevented the development of hypertension in LH rats, suppressed their preglomerular vasoconstriction, and markedly improved their pressure-natriuresis. In perindopril-treated LH, ANG II produced a greater reduction in renal blood flow, glomerular filtration rate, and urinary sodium excretion that was not significantly modified by blockade of thromboxane A2-prostaglandin H2 receptors. These results indicate that the blood pressure level and the renal function of LH rats are closely dependent on an active RAS.
为评估肾素-血管紧张素系统（RAS）在里昂高血压（LH）大鼠肾脏改变中的作用，在早期和长期用培哚普利（从3至15周龄口服，3毫克·千克⁻¹·天⁻¹）阻断RAS后以及急性输注血管紧张素II（ANG II，10或50纳克·千克⁻¹·分钟⁻¹）后，研究了LH大鼠及其正常血压（LN）对照在不同压力水平下的肾功能。在所研究的肾灌注压力范围内（115 - 165毫米汞柱），对照LH大鼠与LN大鼠的区别在于肾小球前血管收缩增强以及压力-利钠曲线变钝。培哚普利完全阻止了LH大鼠高血压的发展，抑制了它们的肾小球前血管收缩，并显著改善了它们的压力-利钠功能。在培哚普利治疗的LH大鼠中，ANG II使肾血流量、肾小球滤过率和尿钠排泄有更大程度的降低，而血栓素A2 - 前列腺素H2受体阻断对此无明显影响。这些结果表明，LH大鼠的血压水平和肾功能密切依赖于活跃的RAS。
