Abel K M, O'Keane V, Murray R M
Institute of Psychiatry, London.
Br J Psychiatry. 1996 Jan;168(1):57-60. doi: 10.1192/bjp.168.1.57.
We wished to investigate central serotonergic function in untreated schizophrenia.
Thirteen drug-naive, DSM-III-R schizophrenic patients were compared with sex, race, age, weight and menstrual phase matched controls. Plasma prolactin and cortisol responses to a specific serotonergic probe, d-fenfluramine, were measured along with BPRS ratings.
Prolactin responses were enhanced in schizophrenic patients compared to controls (P < 0.05) and were correlated positively with BPRS items for depression, anxiety and guilt. Baseline cortisol was also raised in those with schizophrenia (P < 0.001).
Central serotonergic tone may be raised in acute, drug-naive schizophrenia and may be associated with the presence of affective symptomatology.
我们希望研究未经治疗的精神分裂症患者的中枢5-羟色胺能功能。
将13名未服用过药物、符合DSM-III-R标准的精神分裂症患者与性别、种族、年龄、体重和月经周期相匹配的对照组进行比较。测量了血浆催乳素和皮质醇对特定5-羟色胺能探针d-芬氟拉明的反应以及简明精神病评定量表（BPRS）评分。
与对照组相比，精神分裂症患者的催乳素反应增强（P < 0.05），并且与BPRS中关于抑郁、焦虑和罪恶感的项目呈正相关。精神分裂症患者的基线皮质醇水平也升高（P < 0.001）。
急性、未服用过药物的精神分裂症患者中枢5-羟色胺能张力可能升高，并且可能与情感症状的存在有关。
