Hatzichristou D G, Omata S, Constantinou C E
Department of Urology, Aristotelian University of Thessaloniki, Greece.
Int J Impot Res. 1995 Dec;7(4):221-31.
We describe a new methodology for direct ex vivo measurements of corporal stiffness. Using a new biosensor, stiffness of the corpora cavernosa was measured in 32 mature male Spraque Dawley rats. Mean stiffness (+/- se) value of the corpora was 8.186 +/- 0.318 gm/cm. The corpora was numerically the stiffest organ, when compared to the bladder and the prostate. Values measured at different points from both corpora showed a quite uniform stiffness (range 7.576-8.835 gm/cm). Hormonal stimulation with DHT was shown to significantly increase prostatic stiffness but not corpora stiffness. Similarly alpha-adrenergic antagonists did not affect corporal stiffness in a statistically significant manner. These results suggest that the influence of hormones and adrenergic stimulation on the passive properties of the corpora is negligible. It is concluded that this new method provides a reproducible new parameter for the measurement of corporal stiffness. It is anticipated that in the future this kind of stiffness measurement may be of use for the evaluation of the biomechanical properties of the corpora and its response to pharmacologic manipulation of the trabecular smooth muscle tone in vivo.
我们描述了一种用于直接离体测量海绵体硬度的新方法。使用一种新的生物传感器，在32只成年雄性斯普拉格-道利大鼠中测量了海绵体的硬度。海绵体的平均硬度（±标准误）值为8.186±0.318克/厘米。与膀胱和前列腺相比，海绵体在数值上是最硬的器官。在两个海绵体不同点测量的值显示出相当均匀的硬度（范围为7.576 - 8.835克/厘米）。用双氢睾酮进行激素刺激显示可显著增加前列腺硬度，但不影响海绵体硬度。同样，α-肾上腺素能拮抗剂对海绵体硬度没有统计学上的显著影响。这些结果表明，激素和肾上腺素能刺激对海绵体被动特性的影响可以忽略不计。结论是，这种新方法为测量海绵体硬度提供了一个可重复的新参数。预计在未来，这种硬度测量可能用于评估海绵体的生物力学特性及其在体内对小梁平滑肌张力药理操纵的反应。
