Ghio A J, Meyer G A, Crapo R O
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
J Thorac Imaging. 1996 Winter;11(1):53-7. doi: 10.1097/00005382-199601110-00005.
Mean pulmonary artery pressure (PAP) has been demonstrated to correlate with measures of pulmonary artery size. We tested the hypothesis that residence at elevated altitudes, a determinant of mean PAP, can be associated with increases in pulmonary artery size on chest radiographs from healthy adults. The study population consisted of three groups of asymptomatic, nonsmoking adults without hazardous respiratory exposures living at altitudes approximating 0 m (group 1, n = 197), 1,400 m (group 2, n = 145), and 2,600 m above sea level (group 3, n = 196). The width of the right descending pulmonary artery (RDPA) was measured at its widest diameter before bifurcation. In a multivariate regression model, significant associations were detected between RDPA width and residence at elevated altitudes (F = 13.84, p = 0.0002), age (F = 32.49, p < 0.0001), and gender (F = 56.10, p < 0.0001), with 36% of the variability of the measure determined by these three variables (r2 = 0.36). Mean RDPA width increased as altitude at residence increased. Larger mean values were noted among older individuals and males. We conclude that residence at altitudes of 1,400 and 2,600 m above sea level is associated with increases in pulmonary artery size on chest radiograph.
已证实平均肺动脉压（PAP）与肺动脉大小的测量值相关。我们检验了这样一个假设：作为平均PAP的一个决定因素，居住在高海拔地区可能与健康成年人胸部X光片上肺动脉大小的增加有关。研究人群包括三组无症状、不吸烟且无有害呼吸道暴露的成年人，他们分别居住在海拔约0米（第1组，n = 197）、1400米（第2组，n = 145）和2600米（第3组，n = 196）的地区。在右肺下动脉（RDPA）分叉前测量其最宽直径。在多变量回归模型中，检测到RDPA宽度与居住在高海拔地区（F = 13.84，p = 0.0002）、年龄（F = 32.49，p < 0.0001）和性别（F = 56.10，p < 0.0001）之间存在显著关联，该测量值36%的变异性由这三个变量决定（r2 = 0.36）。平均RDPA宽度随着居住海拔的升高而增加。在年龄较大的个体和男性中观察到更大的平均值。我们得出结论，居住在海拔1400米和2600米的地区与胸部X光片上肺动脉大小的增加有关。
