Iida K, Takashima S, Ueda K
Department of Pediatrics, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Pediatr Neurol. 1995 Nov;13(4):296-304. doi: 10.1016/0887-8994(95)00192-1.
Eighteen patients with periventricular leukomalacia (PVL) of the focal or widespread type were immunohistochemically studied with respect to myelination and ferritin-containing oligodendrocytes and compared with 23 controls. Morphometric examination of myelination and ferritin-containing oligodendrocytes revealed normal development in the nonnecrotic cerebral white matter of the focal PVL brains. Myelination was mainly impaired in the necrotic or gliotic periventricular white matter of the widespread PVL brains. The expression of lipid components was poorer than that of myelin basic protein and the number of ferritin-containing oligodendrocytes was decreased in the necrotic or diffuse gliotic region of the widespread PVL brains compared to the controls. There was a significant relationship between the number of ferritin-containing oligodendrocytes and the degree of myelination. The impaired myelination in the PVL brains occurred in the necrotic as well as gliotic regions in the cerebral white matter, and may be related to the decrease of normal oligodendrocytes.
对18例局灶性或广泛性脑室周围白质软化症（PVL）患者的髓鞘形成和含铁蛋白少突胶质细胞进行了免疫组织化学研究，并与23例对照进行比较。对髓鞘形成和含铁蛋白少突胶质细胞的形态计量学检查显示，局灶性PVL脑的非坏死性脑白质发育正常。广泛性PVL脑的坏死或胶质化脑室周围白质中的髓鞘形成主要受损。与对照组相比，广泛性PVL脑的坏死或弥漫性胶质化区域中脂质成分的表达比髓鞘碱性蛋白的表达差，且含铁蛋白少突胶质细胞的数量减少。含铁蛋白少突胶质细胞的数量与髓鞘形成程度之间存在显著关系。PVL脑的髓鞘形成受损发生在脑白质的坏死和胶质化区域，可能与正常少突胶质细胞的减少有关。
