大剂量静脉注射免疫球蛋白治疗儿童皮肌炎。

Treatment of childhood dermatomyositis with high dose intravenous immunoglobulin.

作者信息

Vedanarayanan V, Subramony S H, Ray L I, Evans O B

机构信息

Department of Pediatrics, University of Mississippi Medical Center, Jackson 39216, USA.

出版信息

Pediatr Neurol. 1995 Nov;13(4):336-9. doi: 10.1016/0887-8994(95)00195-6.

DOI:10.1016/0887-8994(95)00195-6

PMID:8771171

Abstract

Two children with chronic dermatomyositis who were treated with intravenous immunoglobulin (IVIG) for 28 and 12 months, respectively, are reported. Both patients had received prednisone and immunosuppressive agents prior to IVIG treatments and had experienced significant side effects. Strength and functional abilities improved in both patients in a gradual stepwise fashion with IVIG treatment. One patient achieved remission and continues to do well without any immunosuppressive agents; in the other patient, the dose of oral steroids was reduced and other immunosuppressive agents were discontinued. Use of IVIG was associated with headaches, nausea, and vomiting in both patients. IVIG was an useful adjuvant therapy in these 2 children with dermatomyositis without any significant side effects.

摘要

本文报告了两名分别接受静脉注射免疫球蛋白（IVIG）治疗28个月和12个月的慢性皮肌炎患儿。两名患者在接受IVIG治疗前均已接受泼尼松和免疫抑制剂治疗，并出现了明显的副作用。IVIG治疗后，两名患者的肌力和功能能力均逐步改善。一名患者实现缓解，在未使用任何免疫抑制剂的情况下情况良好；另一名患者口服类固醇剂量减少，其他免疫抑制剂停药。两名患者使用IVIG均出现头痛、恶心和呕吐。IVIG对这两名皮肌炎患儿是一种有用的辅助治疗方法，且无任何明显副作用。