Bodeau-Péan S, Laurent C, Campion D, Jay M, Thibaut F, Dollfus S, Petit M, Samolyk D, d'Amato T, Martinez M
Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs, CNRS, Batiment CERVI. Hôpital de la Pirié-Salpétrière, Paris. France.
Psychiatry Res. 1995 Nov 29;59(1-2):1-6. doi: 10.1016/0165-1781(95)02789-0.
Pharmacological and clinical findings suggest that the dopamine transporter (DAT) gene may be involved in the genetic predisposition to schizophrenia. Linkage of a Taq I VNTR polymorphism in the DAT gene to schizophrenia was studied in multiplex schizophrenic families from Rouen, France (n = 10) and the Island of La Réunion (n = 21). Neither the lod score method nor nonparametric methods (the affected pedigree member method of Weeks and Lange [1988] and the sibling method of Green and Woodrow [1977]) provided any evidence for linkage. An association study, carried out within a group of 91 unrelated schizophrenic patients from Rouen and 91 matched control subjects, examined a 40 base-pair repeat polymorphism located in the 3' nontranslated end of the DAT mRNA. There was no significant difference in allelic or genotypic frequencies between the two groups. These results exclude any substantial involvement of the DAT gene in the pathogenesis of schizophrenia in the population studied.
药理学和临床研究结果表明，多巴胺转运体（DAT）基因可能与精神分裂症的遗传易感性有关。在来自法国鲁昂（n = 10）和留尼汪岛（n = 21）的多重精神分裂症家族中，研究了DAT基因中Taq I VNTR多态性与精神分裂症的连锁关系。无论是对数优势记分法还是非参数方法（Weeks和Lange [1988]的患病家系成员法以及Green和Woodrow [1977]的同胞法）均未提供连锁的任何证据。在一组来自鲁昂的91例无亲缘关系的精神分裂症患者和91例匹配的对照受试者中进行了一项关联研究，检测了位于DAT mRNA 3'非翻译区的一个40个碱基对重复多态性。两组之间的等位基因或基因型频率没有显著差异。这些结果排除了DAT基因在所研究人群的精神分裂症发病机制中的任何实质性参与。
