Martynov A I, Stepura O V, Ostroumov O D
Ter Arkh. 1996;68(2):40-3.
Phenotype was investigated in 86 patients with idiopathic prolapses of atrioventricular valves and in 21 patients with displaced chordae. 10 and 4 markers of connective tissue dysplasia were distinguished for patients with the prolapses and anomalous chordae, respectively. For patients with dysplasia of connective tissue of the heart a modified version of phenotypical length is proposed: norm-anomalous chordae--prolapse of the 1st degree--prolapse of the 2nd degree. For patients with 3 and more markers echo-CG registration is advisable to reject mitral and/or tricuspid valves.
对86例特发性房室瓣脱垂患者和21例腱索移位患者的表型进行了研究。分别为脱垂和异常腱索患者鉴别出10种和4种结缔组织发育异常标志物。对于心脏结缔组织发育异常的患者，提出了表型长度的改良版本：正常-异常腱索-Ⅰ度脱垂-Ⅱ度脱垂。对于有3种及以上标志物的患者，建议进行超声心动图检查以排除二尖瓣和/或三尖瓣病变。
