Kumarasinghe P
Department of Pathology, Faculty of Medicine, Colombo.
Ceylon Med J. 1996 Jun;41(2):57-60.
To evaluate the usefulness of fine needle aspiration biopsy (FNAB) as an initial investigation in the diagnosis of mass lesions and to determine the accuracy of the test in a Sri Lankan setting.
5149 FNAB samples were retrospectively analysed. The lesions were categorised according to the site and as benign, malignant or atypical/suspicious. Initial cytological diagnosis was compared with the histological diagnosis. Overall accuracy rate, and false positive and negative rates for thyroid, breast and lymphnode aspirates were determined.
Department of Pathology, Faculty of Medicine Colombo and Asiri Hospital, Colombo.
There were 3577 thyroids, 1271 breast lumps, 167 lymph nodes, 58 extra-thyroidal head and neck, 61 deep visceral, and 60 miscellaneous lesions. 3596 (69.2%) were benign and 592 (11.3%) malignant. Histological follow up was available for 1092 (24%). The overall accuracy rate for benign and malignant lesions was 94%. False positive and negative rates for thyroid malignancies were 1.6% and 5.1% respectively. There were no false positives for breast malignancies, and the false negative rate was 6.2%. There were no false positives for lymphoid malignancies.
This cost-effective, minimally invasive technique can be applied to assess any accessible lesion with existing facilities in Sri Lanka. The accuracy and false negative and positive rates in this series are similar to those of recognised centres overseas.
评估细针穿刺活检（FNAB）作为肿块病变诊断的初始检查方法的实用性，并确定该检查在斯里兰卡环境下的准确性。
对5149份FNAB样本进行回顾性分析。根据病变部位将病变分为良性、恶性或非典型/可疑。将初始细胞学诊断与组织学诊断进行比较。确定甲状腺、乳腺和淋巴结穿刺液的总体准确率、假阳性率和假阴性率。
科伦坡医学院病理科和科伦坡阿西里医院。
有3577例甲状腺病变、1271例乳腺肿块、167例淋巴结、58例甲状腺外头颈病变、61例深部内脏病变和60例其他病变。3596例（69.2%）为良性，592例（11.3%）为恶性。1092例（24%）有组织学随访结果。良性和恶性病变的总体准确率为94%。甲状腺恶性肿瘤的假阳性率和假阴性率分别为1.6%和5.1%。乳腺恶性肿瘤无假阳性，假阴性率为6.2%。淋巴恶性肿瘤无假阳性。
这种经济高效、微创的技术可应用于斯里兰卡利用现有设施评估任何可触及的病变。本系列研究中的准确率以及假阴性和阳性率与海外公认中心的相似。
