Alexa A, Drăgan M, Popa I, Raica M, Dema E
Department of Histology, University of Medicine and Pharmacy, Timişoara, România.
Rom J Morphol Embryol. 1995 Jul-Dec;41(3-4):121-4.
Bioptic fragments of adipose white tissue taken from trochanterian area from children of 2-22 months old were ultrastructurally investigated. Children were of both sexes, 5 normal and 22 with clinical diagnosis of malnutrition. There were studied many interadipocyte spaces signalling out in cases with malnutrition modifications of different components, some of them related with the degree of malnutrition. There were noted: disorganisation and disappearance of basal membranes of capillaries and glycolema; modifications of endothelial cells with lesions of the capillary wall and free degraded red blood cells; disorganization of the ground substance in small areas or sometimes extended to all matrix of the space; collagen fibres reduced in number and size, and in two cases the presence of collagen fibrils with severe lesions, realeasing an electrondense material, fibrinoid-like; matrix infiltration, in some cases with lipids. In only one interadipocyte space a synaptic button was noted in contact with capillary. In malnutrition lesions of cellular elements of the white adipose tissue the following were observed: adipocytes, fibroblasts, fibrocytes, endothelial cells, mast cells--which in their turn are responsible for modifications of macromolecular structures of the extracellular matrix--glycosaminoglycans, proteoglycans, components of which biosyntheses are cell-dependent.
对取自2至22个月大儿童转子区的白色脂肪组织活检碎片进行了超微结构研究。儿童涵盖男女两性，其中5名正常，22名临床诊断为营养不良。研究了许多脂肪细胞间间隙，这些间隙在营养不良病例中显示出不同成分的改变，其中一些与营养不良程度有关。观察到：毛细血管和糖萼的基底膜紊乱和消失；内皮细胞改变，伴有毛细血管壁损伤和游离降解红细胞；小区域内或有时扩展至整个间隙基质的基质紊乱；胶原纤维数量和大小减少，在两例中存在严重损伤的胶原原纤维，释放出电子致密物质，类纤维蛋白样；基质浸润，在某些情况下伴有脂质。仅在一个脂肪细胞间间隙中发现一个突触小体与毛细血管接触。在白色脂肪组织细胞成分的营养不良损伤中，观察到以下情况：脂肪细胞、成纤维细胞、纤维细胞、内皮细胞、肥大细胞，而这些细胞又依次导致细胞外基质大分子结构的改变——糖胺聚糖、蛋白聚糖，其生物合成成分依赖于细胞。
