Werner M H, Huth J R, Gronenborn A M, Clore G M
Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892-0520, USA.
Trends Biochem Sci. 1996 Aug;21(8):302-8.
Mammalian male sex determination is controlled by a complex hierarchy of gene regulatory proteins and hormones, which promote male gonadal development and regression of the female primordia. At the core of this pathway lies the SRY protein, the master developmental switch for testicular differentiation and hence, the male sex. The three-dimensional structure of the SRY-DNA complex suggests a model of developmental gene regulation in which proteins that alter DNA structure and promote the assembly of higher-order nucleoprotein complexes play an essential role in the timing of cell specialization events.
哺乳动物的雄性性别决定由基因调控蛋白和激素的复杂层级所控制，这些蛋白和激素促进雄性性腺发育以及雌性原基的退化。该通路的核心是SRY蛋白，它是睾丸分化以及雄性性别的主要发育开关。SRY-DNA复合物的三维结构提示了一种发育基因调控模型，其中改变DNA结构并促进高阶核蛋白复合物组装的蛋白质在细胞特化事件的时间安排中起着至关重要的作用。
