Smyth P P, Smith D F, McDermott E W, Murray M J, Geraghty J G, O'Higgins N J
Department of Medicine, St. Vincent's Hospital, University College, Dublin, Ireland.
J Clin Endocrinol Metab. 1996 Mar;81(3):937-41. doi: 10.1210/jcem.81.3.8772554.
Despite extensive study, evidence to support a direct relationship between diseases of the thyroid and breast has not been established. In this study thyroid volume was assessed by ultrasound in 200 patients with breast cancer and 354 with benign breast disease. Results were compared to appropriate female control groups. Both mean thyroid volume (21.1 +/- 1.4 mL) and the percentage of individual patients with enlarged (> 18.0 mL) thyroid glands (41.5%) were significantly greater in the breast cancer group than equivalent values (13.2 +/- 0.5 mL and 10.5%, respectively) in age-matched controls (P < 0.01 in both cases). The mean thyroid volume of 14.5 +/- 0.34 mL in patients with benign breast disease was also significantly greater than that of 12.5 +/- 0.38 mL in younger controls (P < 0.01). The results support a direct association between breast cancer and increased thyroid volume as mean thyroid volumes and the percentage of individual patients with enlarged thyroid glands were similar in those studied both before (20.8 +/- 1.3 mL and 43.0%) and after (21.4 +/- 1.6 mL and 40.0%) therapies for breast cancer. Although there is no evidence that thyroid enlargement represents a risk factor for breast cancer, the results emphasize the importance of raising the consciousness of the coincidence of both disorders.
尽管进行了广泛研究，但支持甲状腺疾病与乳腺疾病之间存在直接关联的证据尚未确立。在本研究中，通过超声对200例乳腺癌患者和354例乳腺良性疾病患者的甲状腺体积进行了评估。将结果与相应的女性对照组进行比较。乳腺癌组的平均甲状腺体积（21.1±1.4 mL）和甲状腺肿大（>18.0 mL）的个体患者百分比（41.5%）均显著高于年龄匹配对照组的相应值（分别为13.2±0.5 mL和10.5%）（两种情况均P<0.01）。乳腺良性疾病患者的平均甲状腺体积为14.5±0.34 mL，也显著大于年轻对照组的12.5±0.38 mL（P<0.01）。结果支持乳腺癌与甲状腺体积增加之间存在直接关联，因为在乳腺癌治疗前（20.8±1.3 mL和43.0%）和治疗后（21.4±1.6 mL和40.0%）研究的患者中，平均甲状腺体积和甲状腺肿大的个体患者百分比相似。虽然没有证据表明甲状腺肿大是乳腺癌的危险因素，但结果强调了提高对这两种疾病并存意识的重要性。
