de Klerk J M, Zonnenberg B A, Krouwer H G, Blijham G H, van Dijk A, van het Schip A D, van Die J, van Rijk P P
Department of Nuclear Medicine, University Hospital Utrecht, The Netherlands.
J Nucl Med. 1996 Mar;37(3):465-7.
Rhenium-186 (tin) hydroxyethylidene diphosphonate (186Re-HEDP), a bone-seeking radiopharmaceutical, has been successfully used in the treatment of patients with painful bone metastases. Toxicity is usually limited to reversible thrombocytopenia. An infrequent but clinically significant side effect is the occurrence of transient cranial neuropathy. We report on two prostatic cancer patients with metastatic bone cancer. Both patients developed transient cranial neuropathy shortly after treatment with 186Re-HEDP. Transient neuropathy of cranial nerves needs to be distinguished from neurological abnormalities caused by disease progression.
