Sparacino G, Cobelli C
Dipartimento di Elettronica ed Informatica, Università di Padova, Italy.
Technol Health Care. 1996 Apr;4(1):87-95.
Insulin secretion rate (ISR) in vivo is reconstructed by deconvolution from plasma concentration of C-peptide (CP), a peptide with linear kinetics which is co-secreted with insulin but is not extracted by the liver. Deconvolution requires the knowledge of the CP impulse response. A two-exponential (2E) model is usually chosen to describe the CP impulse response but a one-exponential (1E) model is also used in the literature. The purpose here is to discuss the domain of validity of the 1E model in reconstructing the ISR by deconvolution. In particular, we show that the 1E model can be reliably used only if the ISR spectrum is concentrated in a narrow frequency band and a suitable input is designed for its identification.
体内胰岛素分泌率（ISR）是通过对C肽（CP）血浆浓度进行反卷积来重建的，C肽是一种具有线性动力学的肽，它与胰岛素共同分泌，但不被肝脏提取。反卷积需要了解CP脉冲响应。通常选择双指数（2E）模型来描述CP脉冲响应，但文献中也使用单指数（1E）模型。这里的目的是讨论1E模型在通过反卷积重建ISR时的有效性范围。特别是，我们表明，只有当ISR谱集中在一个窄频带内并设计了合适的输入用于其识别时，1E模型才能可靠地使用。
