George J, John G T, Oommen R, Jacob S, Jacob C K, Shastry J C
Department of Nephrology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.
Nephron. 1996;73(2):154-7. doi: 10.1159/000189032.
Glomerular filtration rate (GFR) was measured in 9 voluntary male kidney donors by scintigraphy. In the basal state, the mean GFR was 96.1 +/- 22 ml/min/1.73 m2. Four weeks after donor nephrectomy, the GFR of the remaining kidney had increased by 22.8 +/- 20.7% (p < 0.05). A protein meal given at this time failed to significantly augment the GFR. The GFR of the grafted kidney increased by 59.7 +/- 24.4% after 6 months (p < 0.01). Renal functional reserve was thus demonstrated in the remaining kidney and the allograft, though a further reserve could not be elicited in the remaining kidney.
