Okuizumi K, Onodera O, Seki K, Tanaka H, Namba Y, Ikeda K, Saunders A M, Pericak-Vance M A, Roses A D, Tsuji S
Department of Neurology, Brain Research Institute, Niigata University, Japan.
Ann Neurol. 1996 Aug;40(2):251-4. doi: 10.1002/ana.410400220.
To determine whether the association of the very low density lipoprotein receptor (VLDL-R) gene with Alzheimer's disease (AD), which has recently been identified in Japanese AD patients, is commonly observed in AD patients of other ethnic backgrounds, we have investigated the allele frequency of the polymorphic CGG repeat in the 5'-UTR of the VLDL-R gene using a data set of 84 Caucasian AD patients with 104 Caucasian controls. Although the allele frequency of the 8-repeat allele was slightly lower, and that of 9-repeat allele was slightly higher, in the Caucasian AD patients than in Caucasian controls, the differences were not statistically significant. Multiple logistic regression analysis using apolipoprotein E4 (APOE4) allele, 5, 8-, or 9-repeat allele of the VLDL-R gene, sex, and age at onset as the predictors revealed that only the APOE4 allele was significantly associated with AD in the data set of the Caucasian AD patients and controls.
为了确定极低密度脂蛋白受体（VLDL-R）基因与阿尔茨海默病（AD）之间的关联（这种关联最近在日本AD患者中被发现）是否在其他种族背景的AD患者中普遍存在，我们使用了一个包含84名白种人AD患者和104名白种人对照的数据集，研究了VLDL-R基因5'-UTR中多态性CGG重复序列的等位基因频率。尽管与白种人对照相比，白种人AD患者中8重复等位基因的频率略低，9重复等位基因的频率略高，但差异无统计学意义。以载脂蛋白E4（APOE4）等位基因、VLDL-R基因的5、8或9重复等位基因、性别和发病年龄作为预测因子进行的多因素logistic回归分析显示，在白种人AD患者和对照的数据集中，只有APOE4等位基因与AD显著相关。
