García-Rafanell J, Lasunción M A, Morell J, Herrera E
Rev Esp Fisiol. 1977 Jun;33(2):103-7.
Fed and 24 h fasted rats were treated by stomach tube with different doses of either tolbutamide or gluypentide and they were compared with controls treated with placebo. At low doses glypentide was ten times more effective as hypoglycemic agent than tolbultamide whereas it was only twice as effective in the fasted rats. Supramaximal doses of either drug produced the same effect decreasing blood glucose levels. Both drugs were able to decrease the rise of blood ketones in fasted rats, but the comparative effect was not parallel to the one observed on glycemia and not proportional to the doses used. The different responses are interpreted as function of the hypoglycemic effect, which would be mainly mediated through the insulinotropic action of these drugs, while the hypoketonemic would be the result of both their insulinotropic effect and their direct action on lipolysis and ketogenesis.
给喂食的大鼠和禁食24小时的大鼠经胃管给予不同剂量的甲苯磺丁脲或格列戊脲，并与给予安慰剂的对照组进行比较。低剂量时，格列戊脲作为降血糖药的效力是甲苯磺丁脲的10倍，而在禁食大鼠中其效力仅为甲苯磺丁脲的2倍。两种药物的超最大剂量产生相同的降低血糖水平的效果。两种药物都能够降低禁食大鼠血酮的升高，但比较效果与在血糖上观察到的效果不平行，且与所用剂量不成比例。不同的反应被解释为降血糖作用的函数，这主要是通过这些药物的促胰岛素作用介导的，而低酮血症则是它们的促胰岛素作用以及它们对脂肪分解和生酮作用的直接作用的结果。
