右旋丙氧芬对大鼠脑和肝脏氧化磷酸化的影响（作者译）
[Effect of dextropoxyphene on oxidative phosphorylation in brain and liver of rat (author's transl)].
作者信息
Saiz I, González de Zárate J L, Velasco Z A
出版信息
Rev Esp Fisiol. 1977 Jun;33(2):109-12.
PMID:877377
Abstract
Dextropropoxyphene hydrochloride increases significantly oxygen uptake in whole rat brain homogenates at concentrations of 10(-4), 10(-5), 10(-6) M when using sucrose 0.25 M pH 7.4 as incubation medium. If substrate and cofactors are added to the sucrose, this drug decreases oxygen uptake at 10(-3) M concentration in brain and liver rat homogenates, and it also decreases significantly the P:O quotient of mitochondria in both organs by uncoupling the oxidative phosphorylation.
摘要
当使用0.25M蔗糖（pH 7.4）作为孵育介质时，盐酸右丙氧芬在浓度为10^(-4)、10^(-5)、10^(-6)M时可显著增加全脑匀浆中的氧摄取。如果在蔗糖中添加底物和辅助因子，该药物在10^(-3)M浓度时会降低大鼠脑和肝匀浆中的氧摄取，并且通过解偶联氧化磷酸化，它还会显著降低两个器官中线粒体的P:O比值。
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