钾通道阻断并不改变多巴胺对新纹状体切片的调节作用。

Potassium channel blockade does not alter the modulatory effects of dopamine in neostriatal slices.

作者信息

Altemus K L, Levine M S

机构信息

Mental Retardation Research Center, University of California, Los Angeles 90024-1759, USA.

出版信息

Brain Res. 1996 Apr 29;718(1-2):212-6. doi: 10.1016/0006-8993(96)00124-2.

DOI:10.1016/0006-8993(96)00124-2

PMID:8773790

Abstract

This study assessed the contribution of K+ conductances to dopamine (DA)-induced modulation of evoked depolarizing synaptic responses (DPSPs) in neostriatal slices obtained from rats. Intracellular recordings of membrane properties and DPSPs evoked by local electrical stimulation were obtained from cells bathed in standard artificial cerebrospinal fluid (ACSF), 5 mM Cs+ in ACSF, 20 mM tetraethylammonium in ACSF, or 1 mM 4-aminopyridine in ACSF. DA altered response amplitude in approximately equal proportions regardless of the presence or absence of these K(+)-channel blockers. These findings suggest that K+ conductances do not provide a major contribution to DA-induced changes in DPSPs in the neostriatum.

摘要

本研究评估了钾离子电导对从大鼠获取的新纹状体切片中多巴胺（DA）诱导的诱发去极化突触反应（DPSP）调制的贡献。通过细胞内记录膜特性以及由局部电刺激诱发的DPSP，这些细胞分别浸浴在标准人工脑脊液（ACSF）、含5 mM Cs⁺的ACSF、含20 mM四乙铵的ACSF或含1 mM 4-氨基吡啶的ACSF中。无论这些钾离子通道阻滞剂是否存在，DA均以大致相同的比例改变反应幅度。这些发现表明，钾离子电导对新纹状体中DA诱导的DPSP变化贡献不大。