慢性暴露于亚阈值浓度的喹啉酸和丙二酸对大鼠纹状体的协同作用。

Synergistic effects of chronic exposure to subthreshold concentrations of quinolinic acid and malonate in the rat striatum.

作者信息

Bazzett T J, Falik R C, Becker J B, Albin R L

机构信息

Department of Neurology, University of Michigan, Ann Arbor 48104-1687, USA.

出版信息

Brain Res. 1996 Apr 29;718(1-2):228-32. doi: 10.1016/0006-8993(96)00143-6.

DOI:10.1016/0006-8993(96)00143-6

PMID:8773793

Abstract

Adult rats received chronic intrastriatal dialytic exposure to quinolinic acid (QUIN), malonate, or a combination of QUIN and malonate. The combination of subthreshold concentrations of QUIN (4 mM) and malonate (400 mM) produced lesions larger than did either QUIN or malonate alone. The neurotoxic effect of QUIN combined with malonate was subsequently blocked by co-administration of the NMDA receptor antagonist MK-801 (1 mM). These findings indicate that malonate synergistically enhances NMDA receptor mediated excitotoxicity.

摘要

成年大鼠接受了纹状体内慢性透析暴露于喹啉酸（QUIN）、丙二酸或QUIN与丙二酸的组合。亚阈值浓度的QUIN（4 mM）和丙二酸（400 mM）联合使用产生的损伤比单独使用QUIN或丙二酸更大。随后，通过共同给予NMDA受体拮抗剂MK-801（1 mM），可阻断QUIN与丙二酸联合产生的神经毒性作用。这些发现表明，丙二酸可协同增强NMDA受体介导的兴奋性毒性。