地塞米松可减轻用肿瘤坏死因子α处理的10日龄大鼠的低血糖症状。

Dexamethasone attenuates hypoglycemia in ten day old rats treated with TNF alpha.

作者信息

Battelino T, Goto M, Zeller W P

机构信息

Children's Hospital at Loyola, Maywood, IL, USA.

出版信息

Res Commun Mol Pathol Pharmacol. 1996 May;92(2):149-54.

PMID:8774068

Abstract

Hypoglycemia during septic shock is a common and life-threatening sign in the newborn. TNF alpha is an important cytokine in endotoxic shock. The present study was performed to investigate if TNF alpha induces hypoglycemia and if dexamethasone ameliorates the TNF alpha effects in 10 day old rats. TNF alpha induced hypoglycemia and lactacidemia without altering plasma insulin concentration in 10 day old rats. TNF alpha increased GLUT1 mRNA abundance in brain, liver, muscle and fatty tissue, and decreased liver phosphoenolpyruvate carboxykinase (PEPCK) mRNA abundance. Dexamethasone attenuated the hypoglycemia and lactacidemia. Dexamethasone blunted the increase of GLUT1 mRNA abundance and increased the liver PEPCK mRNA abundance. Dexamethasone may be beneficial by promoting gluconeogenesis.

摘要

新生儿脓毒症休克期间的低血糖是一种常见且危及生命的体征。肿瘤坏死因子α（TNFα）是内毒素休克中的一种重要细胞因子。本研究旨在调查TNFα是否会诱发低血糖，以及地塞米松是否能改善10日龄大鼠的TNFα效应。TNFα可诱发10日龄大鼠出现低血糖和乳酸血症，且不改变血浆胰岛素浓度。TNFα增加了脑、肝、肌肉和脂肪组织中葡萄糖转运蛋白1（GLUT1）的mRNA丰度，并降低了肝脏磷酸烯醇式丙酮酸羧激酶（PEPCK）的mRNA丰度。地塞米松减轻了低血糖和乳酸血症。地塞米松减弱了GLUT1 mRNA丰度的增加，并增加了肝脏PEPCK mRNA丰度。地塞米松可能通过促进糖异生而有益。