福氏耐格里阿米巴与胆固醇共同培养后毒力降低。
Reduction in virulence of Naegleria fowleri following growth with cholesterol.
作者信息
John D T, McCutchen C V
机构信息
Department of Biochemistry and Microbiology, Oklahoma State University, College of Osteopathic Medicine, Tulsa 74107, USA.
出版信息
Folia Parasitol (Praha). 1995;42(3):236-8.
It has been reported that the virulence of axenically cultivated Entamoeba histolytica increases following growth with cholesterol. The purpose of this study was to determine whether cholesterol would enhance the virulence of axenically cultivated Naegleria fowleri. Amoebae were cultivated in axenic medium with (100 micrograms/ml) or without cholesterol for 6 months and tested in mice for changes in virulence. After 6 months of continuous cultivation. N. fowleri grown with cholesterol was less virulent for mice than the same strain grown without cholesterol.
据报道，无菌培养的溶组织内阿米巴在与胆固醇共同生长后毒力会增强。本研究的目的是确定胆固醇是否会增强无菌培养的福氏耐格里阿米巴的毒力。将阿米巴在含有（100微克/毫升）或不含胆固醇的无菌培养基中培养6个月，并在小鼠中测试毒力变化。连续培养6个月后，与不含胆固醇培养的同一菌株相比，含胆固醇培养的福氏耐格里阿米巴对小鼠的毒力较低。
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