QSAR of thiosemicarbazones derived from formyl- and acyl-diazines designed as antiviral agents.

This study is an approach to the QSAR of certain Thiosemicarbazones (TSCs) with antiherpesvirus activity, shown to be based on inhibition of ribonucleotide reductases (RR). With regard to the inhibition of RR by TSCs no clear mechanism of interaction could emerge. A good correlation was shown to exist between the inhibitory effect and steric properties of substituents. The presence of a 1,2-N ring was also shown to be significant.