Heuschmann D, Butenandt O, Vogel M
Pädiatrische Auxologie, Haunersches Kinderspital, München, Germany.
Eur J Pediatr. 1996 Feb;155(2):77-80. doi: 10.1007/BF02075754.
The myotropic effects of growth hormone (GH) have long been known. An excess of GH as in acromegaly, causes various problems within the circulatory system including cardiac hypertrophy. Although the latter has not been reported as a complication of GH therapy in children, we assessed this possibility in 54 children. Ninety-six echocardiographic studies were performed, in which bisectional images were analysed by Simpson's rule to determine left ventricular volume and mass. Of special interest were 47 results obtained from girls with Ullrich-Turner-syndrome (UTS) treated with supraphysiological doses of GH. Our results showed a significant increase of the myocardial mass in children on GH therapy compared with untreated children, as well as a dose related effect of GH on cardiac mass in girls and cardiac volume in boys. No cardiac hypertrophy, however, could be observed; the increase in muscular mass merely amounting to a normalization of previously low values.
生长激素（GH）的促肌效应早已为人所知。如在肢端肥大症中，GH过量会导致循环系统出现各种问题，包括心脏肥大。尽管儿童生长激素治疗尚未报告出现心脏肥大这一并发症，但我们对54名儿童评估了这种可能性。我们进行了96次超声心动图研究，通过辛普森法则分析二分图像以确定左心室容积和质量。特别值得关注的是，对47名接受超生理剂量生长激素治疗的乌尔里希 - 特纳综合征（UTS）女孩进行的研究结果。我们的结果显示，与未接受治疗的儿童相比，接受生长激素治疗的儿童心肌质量显著增加，并且生长激素对女孩心脏质量和男孩心脏容积有剂量相关效应。然而，未观察到心脏肥大；肌肉质量的增加仅仅是使先前较低的值恢复正常。
