Rudensky A Y
Department of Immunology, University of Washington School of Medicine Seattle 98195, USA.
Semin Immunol. 1995 Dec;7(6):399-409. doi: 10.1006/smim.1995.0044.
CD4 T cells undergo positive and negative selection during thymic development mediated by the interaction of T-cell receptors with MHC class II molecules expressed by thymic epithelial cells and bone marrow-derived antigen presenting cells in the thymus. The majority of MHC molecules are occupied with peptides derived from self proteins. Although the role of self peptides in the negative selection of CD4 cells is well established, the influence of peptides on positive selection of CD4 T cells remained elusive. However, some recent results suggest a role of peptides in the positive selection of CD4 T cells.
在胸腺发育过程中，CD4 T细胞经历阳性和阴性选择，这一过程由T细胞受体与胸腺上皮细胞以及胸腺中骨髓来源的抗原呈递细胞所表达的MHC II类分子相互作用介导。大多数MHC分子被源自自身蛋白质的肽占据。虽然自身肽在CD4细胞阴性选择中的作用已得到充分证实，但肽对CD4 T细胞阳性选择的影响仍不清楚。然而，最近的一些结果表明肽在CD4 T细胞阳性选择中发挥作用。
