Stephens J K, Fischer P W, Marks G S
Science. 1977 Aug 12;197(4304):659-60. doi: 10.1126/science.877578.
The 5alphaH (A : B trans) and 5betaH (A : B cis) steroids are equipotent in inducing delta-aminolevulinic acid synthetase and porphyrin accumulation in chick embryo liver cells maintained in serum-free culture medium. Thus there is no specific steric requirement for porphyrin-inducing activity in steroids.
5αH(A:B反式)和5βH(A:B顺式)类固醇在无血清培养基中培养的鸡胚肝细胞中,诱导δ-氨基乙酰丙酸合成酶和卟啉积累方面具有同等效力。因此,类固醇中诱导卟啉的活性没有特定的空间要求。