将大型临床试验结果应用于急性心肌梗死的管理。
Applying the results of large clinical trials in the management of acute myocardial infarction.
作者信息
Sweeney J P, Schwartz G G
机构信息
Cardiology Section, Department of Veterans Affairs (VA) Medical Center, San Francisco, CA 94121, USA.
出版信息
West J Med. 1996 Mar;164(3):238-48.
Abstract
Mortality from acute myocardial infarction has declined in recent years, largely due to the widespread application of new pharmacologic and mechanical interventions that have been tested in large, prospective, randomized clinical trials. For practicing generalists, we review the key data from such trials that have shaped the current management of patients with acute myocardial infarction. We discuss the roles of thrombolytic therapy, coronary angioplasty, nitrates, beta- and calcium channel blockers, angiotensin-converting-enzyme inhibitors, magnesium, and antiarrhythmic and antithrombotic agents. In addition, we highlight critical unanswered questions in the management of this disorder.
摘要
近年来，急性心肌梗死的死亡率有所下降，这主要归功于新的药物和机械干预措施的广泛应用，这些措施已在大型、前瞻性、随机临床试验中得到验证。对于普通执业医生，我们回顾了这些试验的关键数据，这些数据塑造了目前急性心肌梗死患者的治疗方式。我们讨论了溶栓治疗、冠状动脉血管成形术、硝酸盐、β受体阻滞剂和钙通道阻滞剂、血管紧张素转换酶抑制剂、镁以及抗心律失常和抗血栓药物的作用。此外，我们还强调了该疾病治疗中尚未解决的关键问题。
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本文引用的文献
1
Modern management of acute myocardial infarction.急性心肌梗死的现代管理
Curr Probl Cardiol. 1993 Feb;18(2):81-155. doi: 10.1016/0146-2806(93)90018-w.
2
Immediate angioplasty compared with the administration of a thrombolytic agent followed by conservative treatment for myocardial infarction. The Mayo Coronary Care Unit and Catheterization Laboratory Groups.直接血管成形术与溶栓剂给药后保守治疗心肌梗死的比较。梅奥冠心病监护病房和导管插入实验室小组。
N Engl J Med. 1993 Mar 11;328(10):685-91. doi: 10.1056/NEJM199303113281003.
3
A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction.急性心肌梗死中直接冠状动脉血管成形术与静脉注射链激酶的比较。
N Engl J Med. 1993 Mar 11;328(10):680-4. doi: 10.1056/NEJM199303113281002.
4
A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. The Primary Angioplasty in Myocardial Infarction Study Group.急性心肌梗死直接血管成形术与溶栓治疗的比较。心肌梗死直接血管成形术研究组。
N Engl J Med. 1993 Mar 11;328(10):673-9. doi: 10.1056/NEJM199303113281001.
5
Aspirin as a therapeutic agent in cardiovascular disease. Special Writing Group.阿司匹林作为心血管疾病的治疗药物。特别写作组。
Circulation. 1993 Feb;87(2):659-75. doi: 10.1161/01.cir.87.2.659.
6
Embolic potential, prevention and management of mural thrombus complicating anterior myocardial infarction: a meta-analysis.前壁心肌梗死并发壁血栓的栓塞风险、预防及处理：一项荟萃分析
J Am Coll Cardiol. 1993 Oct;22(4):1004-9. doi: 10.1016/0735-1097(93)90409-t.
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Potential benefits of late reperfusion of infarcted myocardium. The open artery hypothesis.梗死心肌延迟再灌注的潜在益处。开放动脉假说。
Circulation. 1993 Nov;88(5 Pt 1):2426-36. doi: 10.1161/01.cir.88.5.2426.
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