Tatemoto Y, Ohno A, Osaki T
Department of Oral Surgery, Kochi Medical School, Japan.
Eur J Cancer B Oral Oncol. 1996 Jul;32B(4):275-7. doi: 10.1016/0964-1955(95)00092-5.
A rare, minor salivary gland tumour of the hard palate in a middle-aged woman was presented. The small (1.0 X 0.5 cm in diameter) hemispherical tumour was well circumscribed with a fine papillomatous surface. Histopathologically, tumour cells with eosinophilic cytoplasm and a large nucleus were single-strand cuboidal and columnar cells, which showed intraductal growth exhibiting a cribriform pattern. The histological features were distinct from adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma because the tumour lacked the neurotropic infiltration, cord-like proliferation and targetoid arrangement. The tumour could not be identified as a typical salivary-duct carcinoma because Roman bridging, papillary projection, and severe cell atypia were not found. Tumour cells were negative for PAS, Alcian blue, mucicarmine, p53, c-erbB-2, CEA, S-100 protein, alpha-smooth muscle actin, lactoferrin or vimentin. About 5% of the tumour cells were positive for proliferating cell nuclear antigen. Taking these factors into account, together with the clinical features, the name low malignant intraductal carcinoma seems appropriate.
本文报道了一名中年女性硬腭罕见的小唾液腺肿瘤。该小肿瘤（直径1.0×0.5 cm）呈半球形，边界清晰，表面有细小乳头样改变。组织病理学上，肿瘤细胞胞质嗜酸性，核大，呈单排立方状和柱状，呈导管内生长，表现为筛状结构。该肿瘤的组织学特征与腺样囊性癌和多形性低度腺癌不同，因为肿瘤缺乏嗜神经浸润、条索状增生和靶样排列。由于未发现罗马桥接、乳头样突起和严重细胞异型性，该肿瘤不能被认定为典型的涎腺导管癌。肿瘤细胞对PAS、阿尔辛蓝、黏液卡红、p53、c-erbB-2、CEA、S-100蛋白、α-平滑肌肌动蛋白、乳铁蛋白或波形蛋白均呈阴性。约5%的肿瘤细胞增殖细胞核抗原呈阳性。综合考虑这些因素以及临床特征，低恶性导管内癌这一名称似乎较为合适。
