Ross S, Rodriguez W, Khan W
South Med J. 1977 Jul;70(7):855-61. doi: 10.1097/00007611-197707000-00026.
The efficacy of the cephalosporins against gram-positive cocci and some of the gram-negative bacilli together with their relative safety make this family of antibiotics potentially useful in treating pediatric infections, particularly in instances of penicillin hypersensitivity. Newer cephalosporins have broadened the antimicrobial spectral range and may offset some of the previous drawbacks to their use in children. Of potential interest to the pediatrician is the highly active inhibitory effect against Hemophilus influenzae by cefamandole, one of the newer cephalosporin congeners.
头孢菌素类药物对革兰氏阳性球菌和某些革兰氏阴性杆菌的疗效及其相对安全性，使得这类抗生素在治疗儿科感染方面具有潜在的应用价值，尤其是在青霉素过敏的情况下。新型头孢菌素扩大了抗菌谱范围，可能弥补了以往在儿童使用中存在的一些缺点。儿科医生可能感兴趣的是新型头孢菌素同系物之一头孢孟多对流感嗜血杆菌具有高度活性的抑制作用。
