Bukowska D
Department of Neurobiology, University School of Physical Education, Poznań, Poland.
J Hirnforsch. 1996;37(2):159-72.
Projections of the trigeminal sensory nuclear complex (TSNC) onto the cerebellar paramedian lobule (PML) were investigated by the retrograde horseradish peroxidase (HRP) and fluorescent tracers (FB, DY) technique in the rabbit. Following injections of the tracers into the various regions of different sublobules of PML, the retrograde labelling pattern in TSNC was analyzed, especially in relation to the climbing fibre zones identified by retrograde labelling in the inferior olive (Zimny et al., 1989). The present results indicate that projections are bilateral with a clear ipsilateral preponderance. The major projections originate mainly from the dorsolateral and ventromedial regions of the principal trigeminal nucleus (Vp) except its caudal pole. Prominent input is also derived from the rostral (Vir) and caudal (Vic) pars interpolaris of the spinal trigeminal nucleus (Vsp). The cells of origin of the projections are present throughout the entire length of Vir with preference to dorsolateral and dorsal location. In Vic they tend to be distributed in the medial regions of its rostral half. Afferents form the pars oralis (Vo) of Vsp are moderate and arise mainly from the dorsomedial and dorsal regions in its caudal one-third. Projections from the pars caudalis (Vc) of Vsp and the mesencephalic trigeminal nucleus (Vmes) are absent. A topography exists in the trigeminocerebellar projections, however, no clear-cut evidence was obtained for a topical relationship between distribution of neurones in TSNC and projections sites in PML. On the other hand, certain correspondence could be found between subdivisions of TSNC and climbing fibre zones in PML. While zones C3 and C2-lateral appear to receive no trigeminal afferents, zone C1 is supplied by fibres from Vir and Vic. All subdivisions of TSNC project zones C2, D1 and D2. In sublobule f, medial (Dm) and lateral (Dl) composite zone D1 + D2 receive projections from Vic, or Vp and Vir, respectively. The present report provides new detailed data on the trigeminocerebellar system in the rabbit.
采用辣根过氧化物酶（HRP）逆行追踪法和荧光示踪剂（FB、DY）技术，研究了家兔三叉神经感觉核复合体（TSNC）向小脑旁正中小叶（PML）的投射。将示踪剂注入PML不同小叶的各个区域后，分析TSNC中的逆行标记模式，特别是与通过下橄榄核逆行标记确定的攀缘纤维区的关系（Zimny等人，1989年）。目前的结果表明，投射是双侧的，同侧优势明显。主要投射主要起源于三叉神经主核（Vp）的背外侧和腹内侧区域，但不包括其尾极。显著的输入也来自脊髓三叉神经核（Vsp）的极间部头端（Vir）和尾端（Vic）。投射的起源细胞在Vir的全长都有，以背外侧和背侧位置为主。在Vic中，它们倾向于分布在其头端一半的内侧区域。来自Vsp口部（Vo）的传入纤维适中，主要起源于其尾端三分之一的背内侧和背侧区域。来自Vsp尾侧部（Vc）和中脑三叉神经核（Vmes）的投射不存在。三叉小脑投射存在拓扑结构，然而，没有获得明确的证据表明TSNC中神经元的分布与PML中投射部位之间存在局部关系。另一方面，在TSNC的细分和PML中的攀缘纤维区之间可以发现一定的对应关系。虽然C3区和C2外侧区似乎没有三叉神经传入纤维，但C1区由来自Vir和Vic的纤维供应。TSNC的所有细分都投射到C2、D1和D2区。在小叶f中，内侧（Dm）和外侧（Dl）复合区D1+D2分别接受来自Vic或Vp和Vir的投射。本报告提供了关于家兔三叉小脑系统的新的详细数据。
