Munemoto S, Soma M, Kuroda E, Hamada Y, Nakada M
Department of Neurosurgery, Ishikawa Prefectural Central Hospital.
Jpn J Antibiot. 1996 Jun;49(6):658-62.
A patient with intracerebral hematoma suffered from postoperative bacterial meningitis. Staphylococcus aureus was found from CSF. The organism was multiple drug resistant and refractory to antibiotics including piperacillin (PIPC), cephalexin (CEX), cefotaxime (CTX), ceftazidime (CAZ) and latamoxef (LMOX). It was susceptible to cefpirome (CPR). Treatment with CPR resulted in clinical improvement associated with clearing of the organism from CSF. Serum level of CPR was high enough and CPR penetration into the CSF was satisfactory. The results suggest that CPR is an extremely effective antibiotic for meningitis caused by CPR-susceptible bacteria. Evaluation of the CPR penetration into the CSF of adult meningitis was rarely reported. The result we obtained was important in the treatment for the adult meningitis.
一名患有脑内血肿的患者术后发生细菌性脑膜炎。脑脊液中发现金黄色葡萄球菌。该菌株对多种药物耐药，对包括哌拉西林（PIPC）、头孢氨苄（CEX）、头孢噻肟（CTX）、头孢他啶（CAZ）和拉氧头孢（LMOX）在内的抗生素均耐药。它对头孢匹罗（CPR）敏感。使用CPR治疗后临床症状改善，脑脊液中的细菌清除。CPR的血清水平足够高，且CPR在脑脊液中的渗透情况令人满意。结果表明，CPR是治疗由对其敏感细菌引起的脑膜炎的一种极其有效的抗生素。关于成人脑膜炎患者脑脊液中CPR渗透情况的评估报道很少。我们得到的结果对成人脑膜炎的治疗具有重要意义。
