Windle M
Research Institute on Addictions, Buffalo, New York 14203, USA.
J Stud Alcohol. 1996 Jul;57(4):378-86. doi: 10.15288/jsa.1996.57.378.
This study used data from the National Longitudinal Survey of Youth (NLSY) to test hypotheses relevant to the discriminative validity of a trichotomous family history of problem drinking index. Early onset substance use, adolescent antisocial behaviors and lifetime alcohol and illicit drug use were used as criterion variables.
Prospective, longitudinal survey data from over 9,000 young adult subjects (ages 23-30 yrs) in the NLSY archive were used to evaluate several hypotheses regarding familial risk of alcoholism.
General support for discriminant validity was indicated, as the high density familial risk group differed from the moderate (paternal or maternal problem drinking only) and low-risk groups with regard to a somewhat earlier onset of marijuana use, higher levels of antisocial behaviors in adolescence (especially substance-related offenses and property offenses) and higher levels of lifetime marijuana and cocaine use. The high- and moderate-risk groups differed from the low-risk group with regard to alcohol use and alcohol-disordered problems (e.g., negative consequences, dependency symptoms).
Risk associated with high familial problem-drinking density includes an earlier onset of illicit substance use, higher rates of lifetime marijuana and cocaine use and more frequent adolescent antisocial behavior. The general pattern of the findings was robust for men and women and suggests that high-risk status may reflect both a high genetic loading and a high environmental risk loading.
本研究使用来自全国青年纵向调查(NLSY)的数据,以检验与饮酒问题三分法家族史指数的区分效度相关的假设。将早期物质使用、青少年反社会行为以及终生酒精和非法药物使用作为标准变量。
使用NLSY档案中9000多名年轻成人受试者(年龄在23 - 30岁之间)的前瞻性纵向调查数据,来评估有关酒精中毒家族风险的若干假设。
表明对区分效度有普遍支持,因为高密度家族风险组在大麻使用开始时间稍早、青少年期反社会行为水平较高(尤其是与物质相关的犯罪和财产犯罪)以及终生大麻和可卡因使用水平较高方面,与中度风险组(仅父亲或母亲有饮酒问题)和低风险组存在差异。高风险组和中度风险组在酒精使用和酒精紊乱问题(例如负面后果、依赖症状)方面与低风险组存在差异。
与高家族饮酒问题密度相关的风险包括非法物质使用开始时间较早、终生大麻和可卡因使用率较高以及青少年期反社会行为更频繁。研究结果的总体模式在男性和女性中都很稳健,表明高风险状态可能既反映了高遗传负荷,也反映了高环境风险负荷。