Schmidt H G, Schmid A, Domschke W
Medizinische Klinik I, University of Erlangen-Nuremberg, Germany.
Z Gastroenterol. 1996 Jul;34(7):428-33.
The neuroendocrine complex of the gastrointestinal tract is defined as the presence of neuroendocrine cells in the lamina propria and in direct contact with nerve fibres of Meissner's plexus. The entire complex is separated from the interstitium by a basement membrane. To date, only a few studies have been published on the neuroendocrine complex. In this prospective electron microscopic study, we investigated the neuroendocrine complex of the stomach in 21 patients with pernicious anemia, and in eight patients with the Zollinger-Ellison syndrome. For each patient, six step biopsies obtained from the stomach at endoscopy were investigated. 16 out of the 21 patients with pernicious anemia, and four of the eight patients with the Zollinger-Ellison syndrome were found to have neuroendocrine complexes in the gastric mucosa. In patients with pernicious anemia who had neuroendocrine complexes more neuroendocrine complex-positive biopsies were found, on average, per patient, and more and larger neuroendocrine complexes, on average, per biopsy, than was the case in patients with the Zollinger-Ellison syndrome. These results show that in the gastric mucosa of patients with pernicious anemia, more marked proliferation of neuroendocrine complexes occur than in patients with Zollinger-Ellison syndrome.
胃肠道的神经内分泌复合体定义为固有层中存在神经内分泌细胞且与梅斯纳丛的神经纤维直接接触。整个复合体通过基膜与间质分隔开。迄今为止，关于神经内分泌复合体的研究仅有少数发表。在这项前瞻性电子显微镜研究中，我们调查了21例恶性贫血患者和8例佐林格-埃利森综合征患者的胃神经内分泌复合体。对于每位患者，研究了在内镜检查时从胃获取的六步活检组织。21例恶性贫血患者中有16例，8例佐林格-埃利森综合征患者中有4例在胃黏膜中发现了神经内分泌复合体。在患有神经内分泌复合体的恶性贫血患者中，平均每位患者发现的神经内分泌复合体阳性活检组织更多，且平均每次活检中神经内分泌复合体更多、更大，这与佐林格-埃利森综合征患者的情况不同。这些结果表明，在恶性贫血患者的胃黏膜中，神经内分泌复合体的增殖比佐林格-埃利森综合征患者更明显。
