Eschwege P, Randrianjohany A, Trifa M, Alexandre L, Blanchet P, Decaux A, Richard C, Charpentier B, Benoit G
Service d'Urologie, Hôpital de Bicêtre, Le Kremlin Bicêtre.
Prog Urol. 1996 Apr;6(2):257-9.
The objective of this retrospective study was to determine whether the difference between the donor's weight (wd) and the recipient's dry weight (wr) could influence the function of renal transplants.
Between 1987 and 1994, 185 patients with a mean age of 43.3 years +/- 12 were transplanted with a locally harvested cadaver kidney, corresponding to 120 men (42.2 years +/- 1.4) and 65 women (45 years +/- 12.8). The weight variation between donors and recipients (wd - wr) was 0.06 for men and 0.22 for women. The serum creatinine of recipients at 1 year was 147 mumol +/- 41.7. We used analysis of variance for univariate statistical analysis and multiple linear regression for multivariate analysis.
On univariate analysis, the serum creatinine at 1 and 2 years was significantly higher (p < 0.02 and p < 0.035 respectively) when the donor's weight was 10% lower than the recipient's weight. Multivariate analysis, taking into account the donor's age and sex and the recipient's serum creatinine, confirmed the influence of the donor-recipient weight difference on serum creatinine at 2 years (p0.03), but also the role of the donor's age at 1 and 2 years (p < 0.0001 and p < 0.0004, respectively).
In our study, the donor-recipient weight difference was a factor influencing the recipient's serum creatinine at 2 years. The donor's age also influences the recipient's serum creatinine, 1 and 2 years after renal transplantation.
本回顾性研究的目的是确定供体体重（wd）与受体干体重（wr）之间的差异是否会影响肾移植的功能。
1987年至1994年间，185例平均年龄为43.3岁±12岁的患者接受了本地获取的尸体肾移植，其中男性120例（42.2岁±1.4岁），女性65例（45岁±12.8岁）。供体与受体之间的体重差异（wd - wr）男性为0.06，女性为0.22。受体术后1年的血清肌酐为147μmol±41.7。我们使用方差分析进行单变量统计分析，多元线性回归进行多变量分析。
单变量分析显示，当供体体重比受体体重低10%时，术后1年和2年的血清肌酐显著更高（分别为p < 0.02和p < 0.035）。多变量分析考虑了供体的年龄、性别以及受体的血清肌酐，证实了供受体体重差异对术后2年血清肌酐的影响（p0.03），同时也证实了供体年龄在术后1年和2年的作用（分别为p < 0.0001和p < 0.0004）。
在我们的研究中，供受体体重差异是影响受体术后2年血清肌酐的一个因素。供体年龄也会影响肾移植术后1年和2年受体的血清肌酐。
