Peşkircioğlu L, Karabulut A, Deniz E, Germiyanoğlu C, Erol D
Department of Urology, Ministry of Health Ankara Hospital, Turkey.
Br J Urol. 1996 Apr;77(4):563-5. doi: 10.1046/j.1464-410x.1996.89414.x.
To investigate the effects of pentoxifylline on penile blood flow and potency in patients with erectile dysfunction due to borderline arterial insufficiency.
Following a routine diagnostic evaluation, 36 patients with borderline arterial disease diagnosed using penile duplex ultrasonography were included in the study. Of these patients, 20 (mean age 54 years, range 40-66) received 1.2 g of pentoxifylline daily, divided into three doses orally, for 2 months and 16 (mean age 54 years, range 34-65) received a placebo. Peak systolic velocities (PSVs) before and after the treatment were compared with those in patients receiving a placebo. The clinical improvement in erectile function was also evaluated.
Twelve of 20 patients receiving pentoxifylline had an increase in PSV at the end of the treatment period. The mean change in PSV achieved by pentoxifylline treatment (6.25 cm/s) was significantly higher than that achieved by the placebo (0.38 cm/s). Seven patients had a positive response (successful coitus achieved after treatment with pentoxifylline). No serious side-effects occurred.
Pentoxifylline was well tolerated and could increase penile arterial inflow, shown objectively as an increase in PSV on penile duplex ultrasonography. These findings should encourage further studies of the efficacy of pentoxifylline in the treatment of impotence.
探讨己酮可可碱对临界动脉供血不足所致勃起功能障碍患者阴茎血流及勃起功能的影响。
在进行常规诊断评估后，36例经阴茎双功能超声诊断为临界动脉疾病的患者纳入本研究。其中20例患者（平均年龄54岁，范围40 - 66岁）每日口服1.2 g己酮可可碱，分三次服用，共2个月；16例患者（平均年龄54岁，范围34 - 65岁）服用安慰剂。将治疗前后的收缩期峰值流速（PSV）与服用安慰剂的患者进行比较。同时评估勃起功能的临床改善情况。
接受己酮可可碱治疗的20例患者中，12例在治疗期末PSV增加。己酮可可碱治疗导致的PSV平均变化（6.25 cm/s）显著高于安慰剂组（0.38 cm/s）。7例患者有阳性反应（己酮可可碱治疗后成功性交）。未发生严重副作用。
己酮可可碱耐受性良好，可增加阴茎动脉血流，阴茎双功能超声检查显示为PSV增加。这些发现应鼓励进一步研究己酮可可碱治疗阳痿的疗效。
