Skliarov O Ia
Fiziol Zh (1994). 1995 May-Aug;41(3-4):9-13.
The combined action of acetylcholine (in a dose of 0.5 mg/kg), ATP (0.5 mg/kg) and histamine (0.05 mg/kg) on the secretory function of the gastric glands has been studied. Combined action of acetylcholine and histamine has induced an increase in the secretion volume rate, acid producing and pepsin discharge functions of the gastric glands. The ATP effect of the background of histamine-stimulated secretion increased acid production and pepsin discharge but less than acetylcholine and histamine did. Simultaneous action of acetylcholine, ATP and histamine has led to potentiation of acetylcholine and ATP effects of the volumetric secretory rate and to their summarized action on pepsin discharge. The conclusion is made that activation of the secretory processes with simultaneous action of the above-mentioned mediatory substances is associated with the participation of corresponding intracellular secondary messengers and start of some cascade reactions.
研究了乙酰胆碱（剂量为0.5毫克/千克）、ATP（0.5毫克/千克）和组胺（0.05毫克/千克）对胃腺分泌功能的联合作用。乙酰胆碱和组胺的联合作用导致胃腺分泌量速率、产酸和胃蛋白酶分泌功能增加。在组胺刺激分泌的背景下，ATP的作用增加了酸的产生和胃蛋白酶的分泌，但比乙酰胆碱和组胺的作用小。乙酰胆碱、ATP和组胺的同时作用导致乙酰胆碱和ATP对容积分泌速率的作用增强，并导致它们对胃蛋白酶分泌的联合作用。得出的结论是，上述介导物质同时作用激活分泌过程与相应细胞内二级信使的参与和一些级联反应的启动有关。
