West J L, Chowdhury S M, Sawhney A S, Pathak C P, Dunn R C, Hubbell J A
Department of Biomedical Engineering, University of Texas, Austin, USA.
J Reprod Med. 1996 Mar;41(3):149-54.
To compare a novel resorbable hydrogel barrier with two previously studied barriers, oxidized regenerated cellulose and hyaluronic acid, for the prevention of postoperative adhesions.
Two models were employed in the rat uterine horn, one of adhesion formation after devascularization and serosal injury and one of adhesion reformation after adhesiolysis
In the devascularization model, hydrogel treatment reduced the mean extent of adhesion formation from 73% in the control group to 13% (P < .005). Hyaluronic acid pretreatment reduced the extent of adhesion formation to 44% (P < .05), while oxidized regenerated cellulose failed to reduce formation (P > .25). In the adhesiolysis model, treatment with the hydrogel reduced the mean extent of adhesion formation from 87% in the control group to 20% (P < .005). Neither the oxidized regenerated cellulose nor the hyaluronic acid treatments lowered the extent of adhesion formation from the control group (P > .25). The hydrogel barrier was observed to be resorbed over a five-day period and remained adherent to the tissue during resorption.
Resorbable hydrogel barriers are highly effective in the reduction of adhesion formation and reformation in the rat. This probably due to the good biocompatibility and retention of these materials upon the site of application.
比较一种新型可吸收水凝胶屏障与两种先前研究过的屏障（氧化再生纤维素和透明质酸）在预防术后粘连方面的效果。
在大鼠子宫角采用两种模型，一种是血管化和浆膜损伤后粘连形成模型，另一种是粘连松解后粘连重塑模型。
在血管化模型中，水凝胶治疗使粘连形成的平均范围从对照组的73%降至13%（P <.005）。透明质酸预处理使粘连形成范围降至44%（P <.05），而氧化再生纤维素未能减少粘连形成（P >.25）。在粘连松解模型中，水凝胶治疗使粘连形成的平均范围从对照组的87%降至20%（P <.005）。氧化再生纤维素和透明质酸治疗均未降低与对照组相比的粘连形成范围（P >.25）。观察到水凝胶屏障在五天内被吸收，吸收过程中仍附着于组织。
可吸收水凝胶屏障在减少大鼠粘连形成和重塑方面非常有效。这可能归因于这些材料良好的生物相容性及其在应用部位的留存。
