Swaving M, van Houwelingen H, Ottes F P, Steerneman T
BAZIS, Experimental Developments, Leiden, The Netherlands.
Med Decis Making. 1996 Apr-Jun;16(2):143-52. doi: 10.1177/0272989X9601600206.
Receiver operating characteristic (ROC) analysis is the commonly accepted method for comparing diagnostic imaging systems. In general, ROC studies are designed in such a way that multiple readers read the same images and each image is presented by means of two different imaging systems. Statistical methods for the comparison of the ROC curves from one reader have been developed, but extension of these methods to multiple readers is not straightforward. A new method of analysis is presented for the comparison of ROC curves from multiple readers. This method includes a non-parametric estimation of the variances and covariances between the various areas under the curves. The method described is more appropriate than the paired t test, because it also takes the case-sample variation into account.
受试者操作特征（ROC）分析是比较诊断成像系统的普遍认可方法。一般来说，ROC研究的设计方式是让多个阅片者阅读相同的图像，且每张图像通过两种不同的成像系统呈现。已开发出用于比较来自单个阅片者的ROC曲线的统计方法，但将这些方法扩展到多个阅片者并非易事。本文提出了一种新的分析方法，用于比较来自多个阅片者的ROC曲线。该方法包括对曲线下各个区域之间的方差和协方差进行非参数估计。所描述的方法比配对t检验更合适，因为它还考虑了病例样本的变异性。
