Patan S, Munn L L, Jain R K
Department of Radiation Oncology, Massachusetts General Hospital, Boston 02114, USA.
Microvasc Res. 1996 Mar;51(2):260-72. doi: 10.1006/mvre.1996.0025.
Intussusceptive microvascular growth refers to vascular network formation by insertion of interstitial tissue columns, called tissue pillars or posts, into the vascular lumen and subsequent growth of these columns, resulting in partitioning of the vessel lumen. While intussusception has been reported in normal developing organs, its existence in solid tumors has not been previously documented. By observing the growth of the human colon adenocarcinoma (LS174T) in vivo for a period of 6 weeks, we demonstrate that intussusception is an important mechanism of tumor angiogenesis. At the leading edge of the tumor, vascular growth was found to occur by both intussusception and endothelial sprouting. In the stabilized regions, intussusception led to network remodeling and occlusion of vascular segments. The formation of some tissue pillars appears to depend on intravascular blood-flow patterns or changes in intravascular shear stress. The rapid vascular remodeling by intussusception could possibly contribute to intermittent blood flow in tumors.
套叠式微血管生长是指通过将称为组织柱或组织桩的间质组织柱插入血管腔并随后这些柱的生长，导致血管腔分隔从而形成血管网络。虽然在正常发育器官中已报道过套叠现象，但此前尚未记录到其在实体瘤中的存在。通过在体内观察人结肠腺癌（LS174T）6周的生长情况，我们证明套叠是肿瘤血管生成的重要机制。在肿瘤的前沿，发现血管生长通过套叠和内皮细胞芽生两种方式发生。在稳定区域，套叠导致血管网络重塑和血管段闭塞。一些组织柱的形成似乎取决于血管内血流模式或血管内剪切应力的变化。套叠引起的快速血管重塑可能导致肿瘤中的间歇性血流。
