Partlo L A, Sainsbury R S
Department of Psychology, University of Calgary, Alberta, Canada.
Physiol Behav. 1996 Apr-May;59(4-5):887-95. doi: 10.1016/0031-9384(95)02208-2.
The electrophysiological relationship between the hippocampus (HP) and the median raphe nucleus (MRN) was examined in the freely moving rat. Bilateral HP recording electrodes were implanted in all animals (n = 15). In the first group of animals, placement of a monopolar recording electrode in the MRN allowed for simultaneous recording of field activity from the HP and MRN, both prior to and following electrolytic destruction of the medial septum (MS) (n = 10). Immediately following MS lesions, theta activity recorded from both sites was abolished. These data suggest that the MS may serve as a pacing input to both the HP and MRN. In a second group of animals, field activity was recorded from the HP and MRN, both prior to and following electrolytic destruction of the entorhinal cortex (EC) (n = 5). Type 1 theta activity recorded from both the HP and MRN was attenuated by EC lesions; however, detomidine-induced immobility-related theta activity was unaffected by destruction of the EC. In light of these findings, the plausibility of EC inputs to the MRN was discussed. The present results suggest that theta activity recorded from the MRN is dependent on the same neural mechanisms that control theta production in the HP.
在自由活动的大鼠中研究了海马体（HP）与中缝正中核（MRN）之间的电生理关系。在所有动物（n = 15）中植入双侧HP记录电极。在第一组动物中，将单极记录电极置于MRN，以便在电解损毁内侧隔核（MS）之前和之后同时记录HP和MRN的场活动（n = 10）。MS损伤后立即，从两个部位记录到的θ活动均消失。这些数据表明，MS可能作为HP和MRN的起搏输入。在第二组动物中，在电解损毁内嗅皮质（EC）之前和之后记录HP和MRN的场活动（n = 5）。HP和MRN记录到的1型θ活动因EC损伤而减弱；然而，右美托咪定诱导的与不动相关的θ活动不受EC损毁的影响。鉴于这些发现，讨论了EC向MRN输入的合理性。目前的结果表明，从MRN记录到的θ活动取决于控制HP中θ产生的相同神经机制。
