[不同温度下哺乳动物和爬行动物肝脏线粒体呼吸的相关性]

[The correlation of liver mitochondrial respiration in mammals and reptiles at different temperatures].

作者信息

Akhmerov R N, Gibarova S, Allamuratova Sh I, Almatov K T

出版信息

Zh Evol Biokhim Fiziol. 1995 Jul-Aug;31(4):410-5.

Abstract

In the experiments with isolated mitochondria in vitro (25 degrees C) it was shown that the respiration rate in mice was 3-5 times higher compared with agamas; in this case both animal species exhibited close body mass. At the comparison of mice and tortoises with the body mass 25-30 times exceeding the one of mice 4-10 times difference in mitochondrial respiration was found. In addition this difference was more pronounced with caprilate and pyruvate than with succinate used as substrates. High rates of respiration for mice mitochondria are shown to persist at wide temperature range in vitro. However respiration parameters for mice and agamas are close in vitro at the temperature of 37 degrees C for mice mitochondria (the optimal mouse body temperature is about 37 degrees C) and the temperature of 42 degrees C for agama mitochondria (the optimal life temperature for agamas is about 42 degrees C).

摘要

在体外分离线粒体的实验（25摄氏度）中发现，小鼠的呼吸速率比鬣蜥高3至5倍；在这种情况下，两种动物的体重相近。在比较体重比小鼠超出25至30倍的小鼠和乌龟时，发现线粒体呼吸存在4至10倍的差异。此外，以辛酸酯和丙酮酸作为底物时，这种差异比以琥珀酸作为底物时更为明显。研究表明，小鼠线粒体的高呼吸速率在体外较宽的温度范围内都能保持。然而，在37摄氏度（小鼠线粒体的温度，小鼠的最佳体温约为37摄氏度）和42摄氏度（鬣蜥线粒体的温度，鬣蜥的最佳生活温度约为42摄氏度）时，小鼠和鬣蜥的呼吸参数在体外相近。