Gerová M, Pechánová O, Stoev V, Kittová M, Bernátová I, Barta E
Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
Am J Physiol. 1996 Feb;270(2 Pt 2):H685-91. doi: 10.1152/ajpheart.1996.270.2.H685.
In anesthetized dogs, a 4-h, approximately 30% increase in blood pressure induced by constriction of the abdominal aorta brought about an increase in the total RNA content in the left anterior descending coronary artery (LADCA) and the left ventricular (LV) myocardium (9.05 +/- 1.72 and 11.06 +/- 4.68%, respectively) but not in the left circumflex coronary artery (LCCA). Under the same experimental conditions, [14C]leucine incorporation increased in LADCA and LV myocardium (45.34 +/- 13.54 and 58.07 +/- 11.91%, respectively), but not in LCCA. The data indicate an early shift in protein synthesis in LADCA and simultaneously in the myocardium during a short-term pressor event. The difference in the shift of protein synthesis in the two main branches of the left coronary artery was related to the quantitatively different deformation of the LADCA and LCCA due to different deformation of the underlying myocardium and/or of the annulus fibrosus atrioventricularis during changes in the left or right ventricle volume [M. Gerová, E. Barta, M. Stolárik, and J. Gero, Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H1049-H1053, 1992]. The results support the hypothesis that the deformation and/or rate of deformation of cells in the coronary wall may trigger an increase in protein synthesis. Changes in protein synthesis in the myocardium and LADCA were found to be reversible 2 h after releasing the aortic constriction.
在麻醉犬中，腹主动脉缩窄导致血压在4小时内升高约30%，这使得左前降支冠状动脉（LADCA）和左心室（LV）心肌中的总RNA含量增加（分别增加9.05±1.72%和11.06±4.68%），但左旋支冠状动脉（LCCA）中未增加。在相同实验条件下，LADCA和LV心肌中的[14C]亮氨酸掺入增加（分别增加45.34±13.54%和58.07±11.91%），但LCCA中未增加。数据表明，在短期升压事件中，LADCA以及心肌中的蛋白质合成会早期发生改变。左冠状动脉两个主要分支中蛋白质合成改变的差异，与左、右心室容积变化期间，由于底层心肌和/或房室纤维环变形不同，导致LADCA和LCCA在数量上不同的变形有关[M. 杰罗娃、E. 巴尔塔、M. 斯托拉里克和J. 杰罗，《美国生理学杂志》262（心脏循环生理学31）：H1049 - H1053，1992]。这些结果支持以下假说：冠状动脉壁细胞的变形和/或变形速率可能引发蛋白质合成增加。在解除主动脉缩窄2小时后，发现心肌和LADCA中的蛋白质合成变化是可逆的。
