一种含有SH3结构域和免疫受体酪氨酸激活基序的新型信号转导衔接分子的克隆
Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM.
作者信息
Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko K, Munakata H, Endo Y, Fujita T, Sugamura K
机构信息
Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan.
出版信息
Biochem Biophys Res Commun. 1996 Aug 23;225(3):1035-9. doi: 10.1006/bbrc.1996.1290.
We molecularly cloned a cDNA coding for a novel phosphotyrosine molecule with a 70 kDa molecular mass, named STAM (signal transducing adaptor molecule), which is tyrosine-phosphorylated rapidly after stimulation with various cytokines such as IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF. STAM contains an SH3 (Src-homology 3) domain and the ITAM (immunoreceptor tyrosine-based activation motif), suggesting that STAM acts as an adaptor molecule involved in signal transducing pathways from the cytokine receptors.
我们通过分子克隆得到了一个编码新型磷酸化酪氨酸分子的cDNA，该分子分子量为70 kDa，命名为STAM（信号转导衔接分子），在用IL-2、IL-3、IL-4、IL-7、GM-CSF、EGF和PDGF等多种细胞因子刺激后，它会迅速发生酪氨酸磷酸化。STAM含有一个SH3（Src同源结构域3）结构域和ITAM（基于免疫受体酪氨酸的激活基序），这表明STAM作为一种衔接分子参与细胞因子受体的信号转导途径。
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