Cope M T, Georgiou N, Bradshaw J L, Iansek R, Phillips J G
Monash University, Clayton, Victoria, Australia.
J Clin Exp Neuropsychol. 1996 Apr;18(2):276-90. doi: 10.1080/01688639608408282.
Patients with hyperkinetic basal-ganglia disorders (Huntington's disease, HD; and Tourette's syndrome, TS) have difficulty with spatially incongruent stimulus-response configurations, the Simon effect, and with inhibiting inappropriate responses in a conditionality paradigm. However Parkinson's disease (PD) patients with hypokinetic basal-ganglia disorder show normal (for their age) conditionality and congruency effects, probably because the task is extremely sensitive to aging and PD patients are typically older than HD and TS individuals. Overall, HD patients were by far the most affected, reflecting the likely greater involvement of the caudate (with its predominantly cognitive role) than the putamen; the latter structure, with a predominantly motor involvement, is the more affected in PD.
患有运动亢进性基底神经节疾病（亨廷顿舞蹈症，HD；以及图雷特氏综合症，TS）的患者在空间不一致的刺激-反应配置、西蒙效应以及在条件范式中抑制不适当反应方面存在困难。然而，患有运动减退性基底神经节疾病的帕金森病（PD）患者表现出正常的（与年龄相符的）条件性和一致性效应，这可能是因为该任务对衰老极为敏感，且PD患者通常比HD和TS患者年龄更大。总体而言，HD患者受影响最为严重，这反映出尾状核（主要起认知作用）可能比壳核受累更严重；壳核主要参与运动，在PD中受影响更大。
