Institute for Cognitive Neuroscience, Biopsychology, Ruhr-University of Bochum, Bochum, Germany.
Neuropsychologia. 2010 Jan;48(2):366-73. doi: 10.1016/j.neuropsychologia.2009.09.023. Epub 2009 Sep 24.
Response inhibition is a component of executive functions, which can be divided into distinct subprocesses by means of event-related potentials (ERPs). These subprocesses are (pre)-motor inhibition and inhibition monitoring, which are probably reflected by the Nogo-N2 and Nogo-P3, respectively. Here we ask, if these subprocesses may depend on distinct basal ganglia subsystems. We examined response inhibition processes in an extended sample of young and elderly subjects, patients with Parkinson's disease (PD) and Huntington' disease (HD). This combination of groups also allow us to study whether, and to what degree, pathological basal ganglia changes and healthy aging have similar and/or different effects on these processes. We show that subprocesses of response inhibition are differentially modulated by distinct basal ganglia circuits. Processes related to (pre)-motor inhibition appear to be modulated by the nigrostriatal system, and are sensitive to aging and age-related basal ganglia diseases (i.e. PD). Parkinson's disease induces additive effects of aging and pathology. In contrast, inhibition monitoring is most likely modulated by the mesocortico-limbic dopamine system. These processes are equally affected in healthy aging and both basal ganglia diseases (i.e. PD, HD).
反应抑制是执行功能的一个组成部分，可以通过事件相关电位（ERP）将其分为不同的子过程。这些子过程分别是（前）运动抑制和抑制监测，它们可能分别由 Nogo-N2 和 Nogo-P3 反映。在这里，我们想知道这些子过程是否可能依赖于不同的基底神经节子系统。我们在一个扩展的年轻和老年受试者、帕金森病（PD）和亨廷顿病（HD）患者的样本中检查了反应抑制过程。这些组的组合还使我们能够研究病理性基底神经节变化和健康衰老是否对这些过程具有相似和/或不同的影响，以及影响的程度如何。我们表明，反应抑制的子过程受到不同的基底神经节回路的差异调节。与（前）运动抑制相关的过程似乎受到黑质纹状体系统的调节，并且对衰老和与年龄相关的基底神经节疾病（即 PD）敏感。帕金森病会导致衰老和病理的附加效应。相比之下，抑制监测很可能由中脑皮质边缘多巴胺系统调节。这些过程在健康衰老和两种基底神经节疾病（即 PD、HD）中同样受到影响。
