Lomri N, Fitz J G, Scharschmidt B F
Department of Medicine, University of California, San Francisco, 94143-0538, USA.
Semin Liver Dis. 1996 May;16(2):201-10. doi: 10.1055/s-2007-1007232.
The interest of mammalian biologists in ATP-binding cassette (ABC) proteins is relatively recent. However, ABC proteins are widespread in distribution and have long been known to play an important transport role in prokaryotes. The review includes a brief overview of the structure, regulation, and varied functions of ABC proteins in different cell types as well as a synopsis of the emerging role of ABC proteins in human biology and disease. The review then focuses on the established (canalicular secretion of organic cations by the multidrug resistance, or MDR 1, gene product; ductular secretion of fluid and electrolytes mediated by CFTR), probable (biliary phospholipid secretion by the MDR 2 gene product; secretion of non-bile acid organic anions by the multidrug resistance protein, or MRP), and possible (bile acid secretion; biliary secretion of the signaling molecule, ATP; hormone transport) roles of known and novel ABC proteins in hepatobiliary secretion.
哺乳动物生物学家对ATP结合盒（ABC）蛋白的关注相对较新。然而，ABC蛋白分布广泛，并且早就知道它们在原核生物中发挥重要的运输作用。这篇综述简要概述了ABC蛋白在不同细胞类型中的结构、调节和多种功能，以及ABC蛋白在人类生物学和疾病中的新作用概述。然后，该综述重点关注已知和新型ABC蛋白在肝胆分泌中已确定的作用（多药耐药性或MDR 1基因产物介导的有机阳离子的胆小管分泌；CFTR介导的液体和电解质的小胆管分泌）、可能的作用（MDR 2基因产物介导的胆汁磷脂分泌；多药耐药蛋白或MRP介导的非胆汁酸有机阴离子分泌）以及可能的作用（胆汁酸分泌；信号分子ATP的胆汁分泌；激素运输）。
