评估环境暴露对人类遗传和癌症风险的未来研究方向。
Future research directions for evaluating human genetic and cancer risk from environmental exposures.
作者信息
Albertini R J, Nicklas J A, O'Neill J P
机构信息
University of Vermont College of Medicine, Genetics Laboratory, Burlington 05401, USA.
出版信息
Environ Health Perspect. 1996 May;104 Suppl 3(Suppl 3):503-10. doi: 10.1289/ehp.96104s3503.
The utility of biomarkers for evaluating the genotoxicity of environmental exposures is well documented. Biomarkers of both exposure and effect provide bases for assessing human-genotoxicant interactions and may be indicative of future disease risk. At present, there is little information on the predictive value of these assays for either a population or the individuals tested. This paper describes some aspects of biomarker assays, the possible use of susceptibility measures in biomonitoring protocols, and the need for evaluation of disease relevance. A population study involving epidemiologists, geneticists, toxicologists, statisticians, and physicians is proposed to determine the disease relevance of these biomarkers.
生物标志物在评估环境暴露的遗传毒性方面的效用已有充分记载。暴露和效应的生物标志物为评估人类与遗传毒物的相互作用提供了依据，并且可能预示未来的疾病风险。目前，关于这些检测方法对所检测的人群或个体的预测价值的信息很少。本文描述了生物标志物检测的一些方面、生物监测方案中敏感性测量的可能用途以及评估疾病相关性的必要性。建议开展一项由流行病学家、遗传学家、毒理学家、统计学家和医生参与的人群研究，以确定这些生物标志物与疾病的相关性。
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