Chileuitt L, Leber K, McCalden T, Weinstein P R
Department of Neurological Surgery, School of Medicine, University of California, San Francisco 94115, USA.
Surg Neurol. 1996 Sep;46(3):229-34. doi: 10.1016/0090-3019(95)00453-x.
Induced hypertension is one of the few interventions available to reverse acute ischemic neurologic deficit. The purpose of this study was to determine the safety and efficacy of hypertension during prolonged temporary focal ischemia.
Anesthetized rats underwent 2 hours of endovascular middle cerebral artery occlusion. Angiotensin was given to increase mean arterial blood pressure to 40%-60% above baseline during ischemia. Neurologic deficit and infarct size in hypertensive rats were assessed at 72 hours.
Hypertensive rats had smaller infarcts than normotensive controls (mean, 12.40 +/- 3.71% versus 24.19 +/- 2.89; p < 0.05) without hemorrhage. Neuroscores were comparable.
Hypertension safely reduces infarction after 2 hours of focal ischemia in rats.
诱导性高血压是可用于逆转急性缺血性神经功能缺损的少数干预措施之一。本研究的目的是确定在长时间短暂局灶性缺血期间高血压的安全性和有效性。
对麻醉大鼠进行2小时的血管内大脑中动脉闭塞。在缺血期间给予血管紧张素，使平均动脉血压比基线升高40%-60%。在72小时时评估高血压大鼠的神经功能缺损和梗死面积。
高血压大鼠的梗死面积小于正常血压对照组（平均为12.40±3.71%对24.19±2.89；p<0.05），且无出血。神经评分相当。
高血压可安全地减少大鼠局灶性缺血2小时后的梗死面积。
